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Role of carnitine Although data in this setting are sparse, consisting of anecdotal case reports, it has been suggested that carnitine supplementation could hasten resolution of coma, prevent development of hepatic dysfunction and reverse mitochondrial metabolic abnormalities in patients with acute VPA intoxication [22, 70]

In a randomized placebo-controlled trial in 310 healthy adults under 50 years of age, those given a supplement providing 900 mg EPA plus 360 mg DHA per day for 26 weeks had greater improvements on all but one test of speed and accuracy of memory than those given 900 DHA plus 270 mg EPA or placebo