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Symptom Monitoring: Even though serious adverse events did not occur in trials, individual monitoring for headache, gastrointestinal symptoms, or unusual effects allows for early detection of tolerability issues and appropriate management adjustments

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Similarly, 10M of BAY 43-9006 significantly induced hemolysis exclusively in Ringer at 0.4% hematocrit ( p =0.0012), but not in Ringer at 4% hematocrit or in cRPMI at 4% hematocrit