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215,216 The GIP/GLP-1 receptor agonists have an additional agonism effect at the GIP receptor, resulting in increased insulin secretion in a glucose dependent manner and combined effects on appetite regulation and weight loss

doi: 10.3389/FMICB.2018.02928 137 PinoP.PellegrinoG.RonchettiS.MolleaC.BoscoF.OnidaB

This multi-factor concept may explain the difficulty in achieving and maintaining glycemic goals with traditional therapies

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Researchers at UTHealth Houston described orforglipron's potential to become "the Metformin of obesity", a widely accessible, affordable, and scalable first-line treatment

Estimated Patient Costs (at Kaiser Pharmacy) T2D Medications Tier 3