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Food and Drug Administration approved the first GLP-1 drug for type 2 diabetes in 2005 and another, the first for weight loss, in 2014

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Meta-analyses confirm that agents such as liraglutide and semaglutide produce average weight losses of 1015%, while newer dual agonists like tirzepatide (Glucose-dependent Insulinotropic Polypeptide / Glucagon-like peptide-1

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