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The resultant Bdnf flox/flox;Lepr-ires-Cre mice confirmed Cre expression in the dentate gyrus with a dramatic reduction of Bdnf expression ( t (8) = 2.7830, P = 0.0238) but normal levels of LepRb mRNA ( t (8) = 0.0925, P = 0.9286) (Fig
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