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George Ball said the FDA needs to update its policies

Elife 6 , e20674 (2017) Wang, Y., Wang, H., Deng, P., Chen, W., Guo, Y., Tao, T., Qin, J.: In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system

The goal is to find the highest dose you can tolerate comfortably, not to reach the maximum dose as quickly as possible

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Food intake data were obtained via 24-h recall