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In models of lung and breast cancer, targeting Apelin prevented resistance associated with anti-angiogenic therapy by reducing tumor growth, metastasis and improving vessel function [188]

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For endurance athletes, this can be distinctly disadvantageous: accelerated glycogen depletion may precipitate earlier fatigue and reduce sustained performance within a single session, particularly before any long-term adaptations can occur

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These patients were diagnosed with clinical stage I-III, not pretreated with neoadjuvant chemotherapy or radiotherapy and underwent lung resection as a cure

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