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In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]
10.3389/fimmu.2017.01960 Front Immunol
doi: 10.3389/fendo.2022.1043789 Received 14 September 2022 Accepted 21 November 2022 Published 07 December 2022 Volume 13 - 2022 Edited by Luigi Santacroce, University of Bari Aldo Moro, Italy Reviewed by Marialetizia Rastelli, Universit de Lille, France
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B., Alderman, M
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