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Technical difficulties in manufacturing two separate peptide drugs or engineered dual-agonist drugs of high purity, stability, and consistency needed for subcutaneous injection make the development and commercialization of dual GLP-1/amylin combination drugs a significant manufacturing challenge

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Effects of endogenous GIP in patients with type 2 diabetes

doi:10.1179/acb.2008.083 14

Lupus may count as a complication in some areas, particularly given the elevated cardiovascular risk