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Mechanisms Adipose tissue dysfunction in obesity can predispose to metabolic disease by multiple mechanisms including inflammation, increased circulating free fatty acid levels and ectopic lipid accumulation, and alteration of the adipose tissue secretome (Fig
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However, these effects usually dissipate after a few weeks
CII, succinate/rotenone (5 mM/1 M)
The hypothesised mechanisms include increased renal excretion of uric acid and potential effects on purine metabolism, though these require further investigation
10.1146/annurev.pharmtox.47.120505.105122 Annu
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