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& Wiper-Bergeron, N
By up-regulation of inflammatory cytokine genes and enhanced BBB permeability, reactive astrocytes are frequently engaged in processes of neurodegeneration and neuroinflammation
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Am Fam Physician 76:3916 Wu Y, Zhang X, Bardag-Gorce F, Robel RC, Aguilo J, Chen L, Zeng Y, Hwang K, French SW, Lu SC, Wan YJ (2004) Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver
-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Antiinflammatory and Protective Effects In Vitro and In Vivo, and Future Perspectives for the Treatment of Immune-Mediated Inflammatory Diseases
Three main mechanisms drive this: Metabolic adaptation : As you lose weight, your resting metabolic rate drops
