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At the same time, history offers numerous examples of treatments that appeared promising early on but later revealed safety concerns, unexpected adverse effects, or limited long-term benefit
They mimic natural hormones that signal fullness to the brain, making it easier to maintain a calorie deficit without the constant struggle of hunger
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Further supporting this, Lock and colleagues demonstrated that glutathione protects against 2-chloropropionic acid (CPA)-induced cerebellar toxicity by preserving thiol redox equilibrium and potentially interacting with NMDA receptor-mediated pathways
These results were observed in patients with T2DM who were inadequately controlled by diet and exercise alone and who had no prior experience with injectable diabetes therapy [70]
N., Sebag, J
