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Gastrointestinal Issues : Common side effects include nausea, constipation, diarrhea, and gastroparesis (paralysis of the stomach)

40.59 6.55 kg/m 2 ) and Roux-en-Y gastric bypass (RYGB) (46.08 10.63 years

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Ghrelin and its central effects Ghrelin is a 28-amino-acid orexigenic peptide hormone primarily produced and secreted by entero-endocrine cells of the stomach (Kojima et al., 1999)

Of particular note was the lack of persistent receptor interactions for His1 of exendin-4, in contrast to the extensive interactions observed for GLP-1 (His7) and oxyntomodulin (His1), as described above (Fig