Z.WongJ.HussainS
Mysore, V., Kumaresan, M., Garg, A., Dua, A., Venkatram, A., Dua, K., Singh, M., Madura, C., Chandran, R., Rajput, R
Bimagrumab has been tested for ~5y in phase II, and I haven't seen a phase 3 yet
A Reducing agents (such as ascorbic acid, beta-mercaptoethanol, dithiothreitol, and cysteine) and thiol reactive compounds (such as maleimides) interfere with the glutathione assay
Researchers should also recognize that the combinations per-unit efficiency means that a well-designed combination protocol frequently achieves a larger research signal at a lower total compound cost than a single-compound protocol producing the same effect, which is part of why the combination dosing approach dominates the published GH-axis research literature
van Langelaar J, et al