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Mousavi A, et al

Both companies have also made consistent progress in improving their drug supply

Skin lightening: 4 to 8 weeks, more effective on facial & neck pigment if combined with chemical peels or lasers

When pharmacotherapy is needed, alternatives include phentermine-topiramate (Qsymia), which requires monitoring for psychiatric effects and is contraindicated in pregnancy

Novo Nordisk, maker of the Wegovy pill, says the side effects of the oral option are similar to the injectable version

Key mediators such as irisin, BDNF, IL-6, adiponectin, FGF21, and apelin each contribute distinct yet complementary protective actions: irisin inhibits NLRP3 inflammasome activation, attenuates oxidative stress, and reduces pyroptotic cell death (215)