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In systemic lupus erythematosus, platelet activation drives release of extracellular mitochondria and mtDNA, providing circulating mitochondrial antigens and nucleic acids that can be taken up by immune cells and linked to interferon-biased programs (160)
Mild bruising or soreness at the IV site is possible but uncommon
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The activation of these junctions may also induce long-term structural changes, such as the formation of tight associations with pericytes (which may encompass gene expression modulation), determining the stability and maturation of the vasculature [45], or short-lasting effects, like transient changes in endothelial permeability to solutes and circulating cells [46,47,48]
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