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2025, Jan, 10;41(1):27 Hansen KS, Jrgensen SE, Cmert C, Schittz-Christensen B, Bross P, Agergaard J, et al

Additional symptoms of the genetic disorder may become apparent from early childhood: a heightened interest in food and easy weight gain underdeveloped genitals sleep conditions and disorders, including sleep apnea (disrupted breathing while sleeping) and excessive daytime sleepiness language delays and speech problems cognitive issues and learning disabilities behavioral problems, such as stubbornness, temper tantrums, and obsessive-compulsive behaviors like skin picking decreased pain sensitivity thick saliva and tooth issues

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Three patients developed haemophagocytic lymphohistiocytosis, one of whom died