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The complex formed with this glycoprotein undergoes endocytosis in the ileum

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4 As expected with GLP-1 based therapies, in SYNCHRONIZE-1 the most commonly reported adverse events for survodutide were gastrointestinal (GI) events, which were mostly mild to moderate in severity and usually occurring during the dose escalation phase

These studies suggest that strategies combining NAD + boosting with inhibitors of NAD + -consuming enzymes could be a promising approach to mitigate axon degeneration