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Pregnant or breastfeeding women, individuals with an existing medical condition, or those taking medication should consult a healthcare professional before use

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These are not FDA-approved

Rybelsus: The oral version of semaglutide also lists fatigue as a potential adverse reaction in its clinical documentation

Another small trial in obese hypogonadal men compared liraglutide vs testosterone gel over 16 weeks: the liraglutide group lost ~6% body weight and showed rising LH/FSH and SHBG (as mentioned earlier), whereas the testosterone therapy group gained lean mass but lost some endogenous gonadal function

Its mechanism is related to inhibiting the PERK/ATF4 signaling axis activated by HMGB1, reducing downstream SIAH2 expression, and restoring HIPK2 levels (Zhang Q