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The inclusion criteria were as follows: (1) age between 3 months and 20 years, (2) diagnosed with refractory epilepsy, having persistent seizures even after administration of two or more ASMs, (3) history of seizures within 2 weeks before the study, (4) baseline seizure frequency of more than 2 times per month Patients with a broad spectrum of seizure frequency was included to reflect the clinical heterogeneity of refractory epilepsy

The discomfort typically manifests as stiffness upon waking or after periods of inactivity