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When HIF-1 is inactivated, the inhibitory effect of carboplatin and etoposide on cell proliferation is significantly enhanced [66]

Bai, Q., Xu, J., Zhu, W., Huang, C., Ni, X., Zhao, H., et al

Weir MR

N Engl J Med 2015;373:2117-28.ArticlePubMed 37

Nanocarriers can employ passive targeting (enhanced permeability and retention, EPR) and active targeting (ligand modification for receptor-mediated endocytosis) to deliver drugs to bladder cancer cells with greater accuracy, thereby reducing drug toxicity to normal tissues