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In a 52 week study including human insulin (NPH insulin) as comparator (6.7 units/kg/day), Sprague Dawley rats were dosed subcutaneously with insulin degludec at 3.3, 6.7, and 10 units/kg/day, resulting in 5 times the human exposure (AUC) when compared to a human subcutaneous dosage of 0.75 units/kg/day

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