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Lipofuscin is commonly observed in human liver biopsies from patients with CLD 8,9 , which can result from various insults such as high-fat diet 10 , drug 11 , and viral infection 5

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Researchers at the University of California San Diego and several partner institutions analyzed data from a previously published clinical trial of 108 adults with HIVassociated lipohypertrophy, a condition in which excess fat builds up around the abdomen

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If needed, prompt debridement and multidisciplinary intervention are necessary to mitigate complications and reduce mortality

Du Y, Zhang H, Lu J, Holmgren A (2012) Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose