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Together with its cofactor protein S, protein C inactivates coagulation factors and inhibits thrombin release

Oncogenic PIK3CA increases the dependency of cancer cells on glutamine by upregulating the expression of mitochondrial GPT2, which catalyzes the transamination reaction that converts glutamate and pyruvate into -KG and alanine 175

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doi: 10.1016/j.arr.2021.101464 74 Di MecoACurtisMELaurettiEPraticoD

Though rare, MPNSTs are aggressive and spread quickly