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Abstract Pigmentary disorders of the nails are frequent diagnostic and therapeutic challenges

doi: 10.1056/NEJMoa1509225 48 BolliGBMunteanuMDotsenkoSNiemoellerEBokaGWuYet al

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This mechanism produces weight loss of 15 to 22 percent of body weight in clinical trialsfar exceeding metformin's typical 3 to 5 pound reduction