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Serious Safety Risks Prescribing information for GLP-1 medications includes warnings related to: Thyroid C-cell tumors observed in animal studies Pancreatitis Gallbladder disease Kidney-related complications Adherence and Real-World Effectiveness Experts note that results seen in clinical trials may differ from real-world outcomes

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For an actual head-to-head, the TRIUMPH-5 trial is currently comparing retatrutide directly against tirzepatide, with primary completion expected in late 2026

The CDC states that unopened vials in this category should be discarded according to the manufacturers expiration date