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The Congressional Budget Office states that there does not appear to be any direct empirical evidence pointing to a medical cost offset

Buckley et al., "Transcellular stomach absorption of a derivatized GLP-1 receptor agonist," Science Translational Medicine 10(467) (2018)

Its reduced MC1R affinity means melanocyte stimulation is minimal

The calculated binding poses offer highly valuable information and provide insights into the possible effects of each mutation on the enzymatic activity (Table S5)

Many compounded formulations already include B12 or glycine, but additional supplementation may be beneficial depending on your individual needs