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Immunofluorescence staining also showed a marked increase in the number of Ki-67-positive cells and a decrease in the nuclear content of -H2AX and P21 after FOXO4-DRI treatment (Figures 4B,C)

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MOTS-c is frequently explored in research models evaluating mitochondrial-nuclear signaling communication, energy-related signaling balance, and cellular resilience mechanisms in metabolically active tissues

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