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The researchers note that further studies are needed to determine the causality between the drug and the increased incidence of NAION

Semaglutide, a potent GLP-1 receptor agonist, is clinically proven to improve blood sugar levels in adults with type 2 diabetes and, alongside a reduced-calorie diet and increased physical activity, to support significant weight loss

2026 Aug 1:251:229-242

"Recent literature has concluded that the 'evidence does not establish a causal relationship between GLP-1RAs and NAION.' If anyone is experiencing side effects when taking a Lilly medicine, they should talk to their doctor or other healthcare professional. The study adds to the growing body of research examining the weight loss and blood sugar control

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Under the action of a condensing reagent and base, an acyl-coupling reaction was performed on the terminal amino group of Arg34GLP-1(9-37) in the activated compound 2 to yield Compound 4