Sometimes, the sulfate conjugate will be converted into toxic metabolite when the sulfate leaves the compound leaving a highly electrophilic intermediate
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L., Chalk, P
By protecting against this oxidative damage, GPX essentially prevents against degenerative diseases such as atherosclerosis, myocardial ischemia, heart failure, diabetes, pulmonary fibrosis, neurodegenerative disorders, and Alzheimer's disease
Yamada T, Sato S, Sotoyama Y, Orba Y, Sawa H, Yamauchi H, et al