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In April 2016, the FDA released a Drug Safety Communication warning about an increased risk of heart failure with saxagliptin, which stated, Type 2 diabetes medicines containing saxagliptin and alogliptin may increase the risk of heart failure, particularly in patients who already have heart or kidney disease

Given the results from recent studies, the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) recommend that patients with T2D and clinical cardiovascular disease (CVD) with inadequate glucose control despite treatment with metformin should receive an SGLT2 inhibitor or GLP-1 receptor agonist

Many natural GLP-1 supplements include curcumin to help promote metabolic health and sustained energy

Quitting smoking is also recommended

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