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However, because everyones biochemistry is unique, it is still possible to have a systemic reaction

It can indicate peptide aggregation (clumping of denatured peptide molecules), bacterial contamination, or incompatible diluent

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The image is adapted from The Conversation news release

Without carefully designed mechanistic experiments, it is difficult to determine whether the peptide acts directly within central compartments or indirectly through peripheral vascular, immune, or gut-brain signaling pathways