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In this study, it was assumed that using the auto-reduction of the hydroquinone adjacent to the quinone on doxorubicin was a sufficient indicator of the rate of oxidation of a potential redox cycle, either on the hydroquinone or the quinone after reduction
First-in-human biomarker-driven phase I trial of the potent and selective glutaminase-1 (GLS1) inhibitor IACS-6274 (IPN60090) in patients with molecularly selected advanced solid tumors
doi: 10.1038/nature04186 193 JonesD
Wada, T
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Sources Sikiric P, Hahm KB, Blagaic AB, et al
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