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"MOTS-c can significantly enhance physical performance in young, middle-age, and old mice." Reynolds et al., Nature Communications , 2021 [3] The ceiling on all of this is the same ceiling every mitochondrial peptide hits: the outcome data is rodent data

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However, we would suggest that future clinical trials should aim to assess the cost-effectiveness of screening older people with obesity who are undergoing weight management interventions for evidence of sarcopenia, through clinical evaluation including hand grip tests, which are accurate biomarkers for overall strength and function, bone mineral density and consequent fracture risk, and cardiometabolic disease [123]