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Other factors contributing to leadership in the region include increased awareness about the co-morbid diseases associated with obesity, greater physician involvement, vigorous scientific research, and pharmaceutical investment in oral GLP-1 drugs, incretin-based, and multi-agonist drugs

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After needle is completely inserted into the skin, press down on the plunger to release medication into the subcutaneous layer at a slow, steady pace

Common side effects include: Gastrointestinal issues: Nausea, vomiting, constipation, and abdominal pain Injection site reactions: Redness, swelling, and pain Systemic issues: Fatigue, indigestion, heartburn, belching, and hair loss More severe side effects include: Thyroid problems: Medullary thyroid cancer and pancreatitis with severe, persistent abdominal pain Gallbladder problems with symptoms such as upper abdominal pain, fever, jaundice, or clay-colored stools Increased risk of hypoglycemia with symptoms such as dizziness, sweating, confusion, and shakiness Severe vomiting that leads to dehydration and kidney problems Mental health concerns such as depression and suicidal thoughts Vision changes from rapid changes in blood glucose levels Some patients should not use Zepbound, such as those who have or are at risk for medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

Patients with concerns about formulation changes can speak with their prescribing physician before the next refill so a preference can be noted on the prescription if there is a clinical reason to remain on the brand-name product

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