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Pediatr Cardiol 2005;26(5):574-577

It is possible that the decline in therapeutic effect could have been due to the aggressiveness of the cone degeneration in the rd10 mice [34], or potential issues with storing the drug solution during experimentation

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In this context, cytotoxic T-lymphocytes (CD8+) are the main cells implicated in disease pathogenesis.78 However, although antibodies reactive against melanocytes (e.g., anti-MelanA, anti-MCHR1, anti-tyrosinase, anti-gp100, and anti-tyrosine hydroxylase) have elevated serum titers in patients with vitiligo, they do not correlate with disease activity.79 Nevertheless, the literature is controversial, and the exact role of anti-melanocyte antibodies in vitiligo remains unclear