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The same bacterial fermentation producing hydrogen sulfide (sulfur burps) also produces other gases and short-chain fatty acids that can accelerate colonic transit and cause watery stools

They do so by not only inducing the expression of the Foxp3 gene but also prompting dendritic cells and intestinal epithelial cells to synthesize retinoic acid and TGF-1, respectively (59)

Among these, TRElimiting the daily eating window to 412 h, typically with 12-h overnight fastinghas gained popularity due to its practical feasibility and better adherence

Early trials suggested retatrutide might help reduce appetite and improve markers of metabolic health

It is designed to interact with the GLP-1 receptor, a signaling pathway examined in laboratory models related to metabolic regulation, nutrient sensing, and hormone signaling

Barnett MJL et al