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These findings indicate that multi-targeted drug combinations focused on mitochondrial energy metabolism may be a promising direction for migraine prophylaxis

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Notably, most clones were detected in multiple states, for example, ST405-3B in 13 states and ST353-1A in 9, indicating extensive clonal spread

This makes it crucial to identify the pathogen accurately and rapidly to prevent prescribing unnecessary antibiotics and limit antibiotic resistance

Increasing GPx levels is essential for halting oxidative stress and alleviating painful symptoms.The current study reported a significant increase in GPx levels from baseline to end in the NAC group versus controls that reported a decline in GPx levels overtime

These findings imply that emodin protects hepatocytes from APAP-induced liver damage by activating Nrf2-mediated antioxidant stress pathways, inhibiting the NLRP3 inflammasome, and downregulating the cGAS-STING signaling pathway (Shen et al., 2022)