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GLP-1 drugs target the GLP-1 trans-membrane receptor, which is one of a large family of G protein-coupled receptor (GPCR) proteins that straddle cell membranes and transduce chemical signals from outside the cell to its interior

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New Data: Phase 3 TRIUMPH-4 Results (Retatrutide) Eli Lilly just released topline results from the Phase 3 TRIUMPH-4 trial, evaluating the triple hormone receptor agonist retatrutide in patients with obesity and knee osteoarthritis (OA)

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These criteria included established atherosclerotic cardiovascular disease, recent acute coronary syndrome or the presence of risk factors and target-organ damage e.g

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2.5.12 LANCL2 agonism 2.5.12.1 Omilancor LANCL2 is an intracellular receptor implicated in intestinal homeostasis, with LANCL2 agonism showing promising efficacy signals in Phase 2 trials with favorable safety and gut-restricted pharmacokinetics

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