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Synergistic receptor co-activation produces approximately 2021% mean body weight reduction in Phase 3 trials significantly more than semaglutide mono-agonism

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References References Selective and membranepermeable small molecule inhibitors of NNMT Roles of Nicotinamide NMethyltransferase in Obesity and Type 2 Diabetes Nicotinamide Nmethyltransferase inhibition mimics and boosts exercisemediated improvements in muscle function in aged mice Reduced calorie diet combined with NNMT inhibition establishes a healthier gut microbiome in obese mice Kraus et al

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