glp 1 parkinson's disease and neuroprotection GLP-1 Disease: A Comprehensive Review of Biology, Mechanisms and Efficacy GLP-1R agonists protect against Alzheimer's

N6-methyladenosine (m 6 A) demethylase FTO is significantly upregulated in MPP + -stimulated SK-N-SH cells, which suppresses YTH domain family protein 2 (YTHDF2) expression, promotes m 6 A demethylation of BRCA1-associated protein 1 (BAP1) and enhances BAP1 expression, upregulates p53 expression, and inhibits SLC7A11 transcription, thereby increasing MDA, Fe 2+ , and 4-HNE levels and triggering neuronal ferroptosis

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10.1038/nature26162PMID: 29414946

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