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Conclusively, the activation of malate mediated anion/cation exchange is most important to recover pH homeostasis followed by amelioration of H + induced cytosolic acidification
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Furthermore, age-dependent exacerbation of BBB impairment has been reported, with increased permeability to FITC-albumin, concomitant with progressive declines in claudin-5, occludin, and ZO-1 mRNA levels, as well as claudin-5 protein expression in the cortex and striatum [151]
P., Keith, B., Nissim, I., and Simon, M
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