Data availability The image reconstruction data have been deposited in the PDB database under accession code EMD-51272
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Long-term use can positively influence blood glucose levels, increase insulin sensitivity, and improve fat metabolism
Rapid weight loss combined with low fluid intake can produce lightheadedness during demanding physical work
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The SURMOUNT-5 trial, published in The New England Journal of Medicine in May 2025, is the first large randomized study to compare tirzepatide and semaglutide directly in adults with obesity