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It differs from IGF-1 by additional 13 amino acids at the N-terminus and the substitution of arginine with glutamic acid at the 3rd position

H., Harken, A

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The documented synergy comes from pairing a GHRH analog with a GHRP, which acts on a different receptor: Ipamorelin GHRP-2 GHRP-6 Blends pairing two GHRH analogs are sold, but the supra-additive GH release reported in the literature comes from the GHRH + GHRP pairing

Am J Physiol Endocrinol Metab 299:E384E393