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While some studies have demonstrated no greater risk compared to placebos, researchers argue that these studies did not measure semaglutide use over a long enough period
NF - B pathway: inhibits NF - B p65 nuclear translocation, reduces I B phosphorylation, blocks osteoclast activation and bone resorption function
L., Chalk, P
Side effects were consistent with other drugs in the incretin class most commonly nausea, diarrhea, constipation, and vomiting which tended to be more frequent at higher doses
doi:10.3389/fnagi.2021.741923 213
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