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In addition to its peripheral effect, diclofenac and other nonsteroidal antiinflammatory analgesics may have a contraceptive effect (analgesic) in the central nervous system acting on the release of prostaglandins and / or through the neuronal systems which use and catecholamines neurotransmitter serotonin (Pain, 1994, 57: 197-205)
The brand's FAQ content states this is sometimes possible, but notes that a simpler approach is often preferred, and that the clinician prioritizes the most appropriate therapy for each patient's goals rather than defaulting to combining everything available
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