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This, in turn, leads to mitochondrial dysfunction, disrupted metabolism, or energy depletion

This functional activity is supported by a multitude of studies demonstrating that anti-inflammatory M2-like macrophages are induced in various models of pancreatic injury and inflammation and operate to promote -cell survival, proliferation, and maintenance of functional -cell mass, through the release of protective factors, such as IGF-1, epidermal growth factor (EGF), transforming growth factor (TGF), platelet-derived growth factor (PDGF), and Wnt3a (78)

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This approach is used for acute injuries, post-surgical recovery, or situations requiring aggressive tissue repair