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Diabetes Obes Metab 19(3):33647 Buse JB, Klonoff DC, Nielsen LL, Guan X, Bowlus CL, Holcombe JH et al (2007) Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: An interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials
Doing glp-1 alone isn't dangerous but it's the version that tends to produce disappointing long-term outcomes, because the medication does its job and everything around it is left to chance
For weight management, semaglutide 2.4 mg once weekly (Wegovy) is initiated at 0.25 mg and gradually escalated over 16 to 20 weeks to minimize gastrointestinal adverse effects
This is not a unique phenomenon to GLP-1 medications and is similar to what we observe with medications that treat other chronic conditions, like high blood pressure, asthma, or inflammatory bowel disease, Maselli says
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