Though their exact mechanism is unclear, proposed actions include activating DNA repair pathways, stimulating adenosine A 2A receptors, and enhancing extracellular signalregulated kinase/mitogen-activated protein kinase signaling, processes that boost collagen production and reduce tissue breakdown
spread 2030g across each meal
We found this paradox to be explained by GLP-1 delaying gastric emptying and the rate of carbohydrate absorption after a meal, biological actions that dominant direct effects on insulin secretion at the B-cell, both in both normal-weight individuals and in non-diabetic individuals with obesity [6, 10] (Fig
10.3389/fendo.2021.645617 22 Merck (2017)
Soluble fiber slows glucose absorption, preventing the rapid swings that can trigger nausea in GLP-1 users, especially between meals
This effect is separate from the alterations in body mass index that accompany the normal aging process