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Phase 4: Happens after FDA approval, when the drug is already on the market, to monitor long-term use in the general population

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A 2023 review in Frontiers in Neuroendocrinology highlighted heterodimer formation between GHSR-1a and dopamine D1 receptors as a potentially significant mechanism for ghrelins CNS effects

Ozempic is considered safe for use under medical supervision

EuroQol Group, Rotterdam, The Netherlands Beaudet A, Clegg J, Thuresson PO, Lloyd A, McEwan P (2014) Review of utility values for economic modeling in type 2 diabetes

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